Mesothelioma, more precisely known as malignant
mesothelioma is a rare cancer of the mesothelial cells, most commonly those in the
lining that covers the lungs (pleura). Mesothelial cells exist in the lining
(membrane) that covers the outer surface of our body organs. The majority of
people with mesothelioma have been exposed to asbestos at some time during
their life.
Doctors usually divide mesothelioma into three types:
Doctors usually divide mesothelioma into three types:
- Pleural mesothelioma - affects the pleura, the lining surrounding the lungs. This is the most common form.
- Peritoneal mesothelioma - the cancer attacks the lining of the abdomen, the peritoneum. This is the second most common form.
- Pericardial mesothelioma - the cancer attacks the protective layer covering the heart. This is the rarest form.
All three forms of mesothelioma are nearly always caused by
asbestos exposure.
Mesothelioma is an aggressive form of cancer. For the majority of patients there is no cure. Doctors usually focus on improving the quality of life as the disease progresses - making the patient as comfortable as possible.
In the United Kingdom, approximately 2,000 patients are diagnosed with mesothelioma annually. According to the CDC (Centers for Disease Control and Prevention), mesothelioma kills over 2,700 people in the USA every year. According to the Mesothelioma register, deaths from this type of cancer rose more than tenfold from 1969 to 2009 in the UK. About four-fifths of all deaths are among men.
Mesothelioma is an aggressive form of cancer. For the majority of patients there is no cure. Doctors usually focus on improving the quality of life as the disease progresses - making the patient as comfortable as possible.
In the United Kingdom, approximately 2,000 patients are diagnosed with mesothelioma annually. According to the CDC (Centers for Disease Control and Prevention), mesothelioma kills over 2,700 people in the USA every year. According to the Mesothelioma register, deaths from this type of cancer rose more than tenfold from 1969 to 2009 in the UK. About four-fifths of all deaths are among men.
What are the signs and symptoms of mesothelioma?
A symptom is something the patient feels and describes;
while a sign is something other people can see, including doctors and nurses.
For example, a symptom may be pain, while a sign could be a rash.
Exposure to asbestos and asbestos dust can take up to thirty years to show symptoms. Often, patients are diagnosed when the disease is already advanced. Outcomes depend on how early the malignancy can be diagnosed.
Mesothelioma signs and symptoms vary, depending on where in the body the cancer is.
Pleural mesothelioma (tissue surrounding the lungs)
Exposure to asbestos and asbestos dust can take up to thirty years to show symptoms. Often, patients are diagnosed when the disease is already advanced. Outcomes depend on how early the malignancy can be diagnosed.
Mesothelioma signs and symptoms vary, depending on where in the body the cancer is.
Pleural mesothelioma (tissue surrounding the lungs)
- Shortness of breath
- Coughing, often painful
- Unexpected and unexplained loss of weight
- Pain under the rib cage
- Sometimes lumps may be detectable under the skin in the chest area
- Lower back pain
- Discomfort in the side of the chest
- Exhaustion
- Some people may experience sweating, fever, or difficulty swallowing
Peritoneal mesothelioma (lining in the abdomen)
- Unexplained weight loss
- Pain in the abdomen
- Swelling in the abdomen
- Lumps in the abdomen
- Nausea, some patients may experience vomiting
Pericardial mesothelioma (lining in the heart area)
- Low blood pressure
- Shortness of breath
- Fluid retention (edema), often in the legs
- Heart palpitations
- Fatigue, extreme after light exertion
- Chest pain
What are the causes of mesothelioma?
Experts say that prolonged
exposure to asbestos particles is the primary cause of mesothelioma. The risk of developing the disease is closely
linked to asbestos particle dosage - i.e. the likelihood of developing
mesothelioma is directly proportional to how long a person was exposed, and how
much they inhaled.
People in jobs where exposure to asbestos fibers are common have the highest risk of developing the disease. Asbestos was commonly used for insulation, soundproofing, fireproofing, roofing, and ironing board covers.
People in jobs where exposure to asbestos fibers are common have the highest risk of developing the disease. Asbestos was commonly used for insulation, soundproofing, fireproofing, roofing, and ironing board covers.
Industries that may have involved
asbestos exposure for some of their workpeople include constructions sites,
steel mills, shipyards, oil refineries and power plants.
When the asbestos particles or fibers are inhaled or ingested, they build up in the lining of the abdomen, chest or lungs. This accumulation considerably increases the chances of cancerous cells developing.
When asbestos is damaged and particles or fibers are released into the air, the environment can become hazardous to human health. The fibers can be breathed in or swallowed, they get embedded in tissue, and eventually lead to mesothelioma.
Asbestos is a group of minerals that occur naturally. They exist as fibers or bundles. These fibers may be found in soil or rocks and exist in many parts of the world naturally. Asbestos is made of silicon, oxygen and some other elements.
There are two principle types of asbestos fibers:
When the asbestos particles or fibers are inhaled or ingested, they build up in the lining of the abdomen, chest or lungs. This accumulation considerably increases the chances of cancerous cells developing.
When asbestos is damaged and particles or fibers are released into the air, the environment can become hazardous to human health. The fibers can be breathed in or swallowed, they get embedded in tissue, and eventually lead to mesothelioma.
Asbestos is a group of minerals that occur naturally. They exist as fibers or bundles. These fibers may be found in soil or rocks and exist in many parts of the world naturally. Asbestos is made of silicon, oxygen and some other elements.
There are two principle types of asbestos fibers:
- Serpentine asbestos - this is the most common type used in industry. It is known as white asbestos, or chrysotile. The fibers are curly.
- Amphibole asbestos - these include anthophyllite, amosite, actinolite, crocidolite, and tremolite. The fibers are straight, like needles. This type of asbestos, particularly crocidolite, is considered to be more likely to cause cancer. However, even serpentine asbestos has been linked to cancer.
Although asbestos is much less
used today than it used to be, exposure is still possible, and continues to be
a serious problem. Older materials containing asbestos can break down,
releasing a dust composed of tiny particles than can be inhaled or ingested.
Exposure can occur when older buildings are demolished or renovated.
Even family members who never set foot in a working environment that contained asbestos can be exposed. The fibers can be carried home in the workers clothing, and then breathed in by other members of the household.
Asbestos can also be swallowed, as may occur when water flows through asbestos cement pipes. Inhaled asbestos can be coughed up, and then swallowed (when the person swallows the saliva).
WHO (World Health Organization) in 2005 said that approximately 125 million people globally were exposed to asbestos at work in that year, despite their employers having known about the link to cancer and other lung diseases for over six decades. Most work-related exposure today occurs in developing nations.
In much rarer cases, mesothelioma may be linked to irradiation, the inhalation of eronite or some other fibrous silicate, and intrapleural thorium dioxide (Thorotrast - a suspension containing radioactive particles, used in X-ray diagnostics during the 1930s and 1940s, and even in the 1950s in some nations including the USA). Some experts believe that SV40 (simian virus 40) could be involved in the development of the disease.
Even family members who never set foot in a working environment that contained asbestos can be exposed. The fibers can be carried home in the workers clothing, and then breathed in by other members of the household.
Asbestos can also be swallowed, as may occur when water flows through asbestos cement pipes. Inhaled asbestos can be coughed up, and then swallowed (when the person swallows the saliva).
WHO (World Health Organization) in 2005 said that approximately 125 million people globally were exposed to asbestos at work in that year, despite their employers having known about the link to cancer and other lung diseases for over six decades. Most work-related exposure today occurs in developing nations.
In much rarer cases, mesothelioma may be linked to irradiation, the inhalation of eronite or some other fibrous silicate, and intrapleural thorium dioxide (Thorotrast - a suspension containing radioactive particles, used in X-ray diagnostics during the 1930s and 1940s, and even in the 1950s in some nations including the USA). Some experts believe that SV40 (simian virus 40) could be involved in the development of the disease.
How is mesothelioma diagnosed?
After asking certain diagnostic
questions, such as the patient's symptoms, where he/she has worked, medical
history and family history, and carrying out a physical examination, the doctor
may order some imaging scans. This could be a CT scan or X-ray of the abdomen
or chest to rule out any abnormalities. Usually, depending on the results of
the scans, further testing may be recommended.
Biopsy - some tissue is surgically removed so that it can be examined in the laboratory under a microscope. To determine whether a patient has mesothelioma, this will have to be done. How the biopsy is carried out depends on which part of the body is targeted:
Targeting either the chest or abdominal area
Biopsy - some tissue is surgically removed so that it can be examined in the laboratory under a microscope. To determine whether a patient has mesothelioma, this will have to be done. How the biopsy is carried out depends on which part of the body is targeted:
Targeting either the chest or abdominal area
- Fine-needle aspiration - a small needle
is inserted into the abdomen and chest and some fluid or piece of tissue
is removed
Targeting the chest area
- Thoracoscopy - the surgeon inserts a
thoracoscope through a small incision between the patient's ribs. A
thoracoscope is an endoscope for examination of the chest cavity - it is a
tube with a small camera at the end. The surgeon removes a piece of tissue
with special tools.
- Thoracotomy - in this surgical
intervention, the chest is opened between the ribs so that the surgeon can
see the target area and check for signs of cancer. Some tissue may also be
removed and sent to the laboratory for testing.
Targeting the abdominal area
- Laparoscopy - a small incision is made in
the abdominal wall, a laparoscope is inserted through the incision into
the abdomen, where the surgeon can have a look. The laparoscope is a long
tube with a camera at the end. With specialized tools, tissue samples can
be removed.
- Laparotomy - the surgeon opens the
abdomen and has a look. Sometimes tissue samples may be removed and sent
to the lab.
When the tissue or fluid sample is
viewed through a microscope, the pathologist can tell whether there is
malignancy (e.g. malignant mesothelioma), what types of cells are involved, and
how advanced the cancer is. How advanced a cancer is, defining it, is called Staging.
Staging - in medicine, specifically cancer, staging is the process of carrying out tests and examinations to determine the extent of the cancer, how advanced it is, and whether it has metastasized (spread from its original site to other parts of the body).
As soon as mesothelioma has been confirmed (diagnosed), other tests will be ordered to help determine the stage of the cancer. These may include such scans as CT, MRI (magnetic resonance imaging), PET (positron emission tomography), or a chest X-ray. What type of scan is used depends on several different factors.
When all the data is gathered together, the health care professional will assign the cancer a stage. The staging below is for pleural mesothelioma (lungs):
Staging - in medicine, specifically cancer, staging is the process of carrying out tests and examinations to determine the extent of the cancer, how advanced it is, and whether it has metastasized (spread from its original site to other parts of the body).
As soon as mesothelioma has been confirmed (diagnosed), other tests will be ordered to help determine the stage of the cancer. These may include such scans as CT, MRI (magnetic resonance imaging), PET (positron emission tomography), or a chest X-ray. What type of scan is used depends on several different factors.
When all the data is gathered together, the health care professional will assign the cancer a stage. The staging below is for pleural mesothelioma (lungs):
- Stage 1 - the cancer is localized. It is
still inside the lining around the lung. It has not spread out.
- Stage 2 - the cancer may have spread to a
lung or the diaphragm.
- Stage 3 - the cancer may have reached the
lymph nodes, and possibly other parts of the chest
- Stage 4 - the cancer has either spread
more extensively in the chest, or may even have reached other parts of the
body far from the original site. It may have reached other lymph nodes, or
even the brain.
What are the treatment options for
mesothelioma?
The treatment the doctor will
recommend depends on several factors, including:
- Where the cancer is
- The stage of the cancer (how advanced it
is)
- The patient's general health and age
Sadly, this type of cancer is
usually spotted when it has been progressing for a while. Add to this the fact
that mesothelioma is usually an aggressive type of cancer, and you have two
reasons why so few patients are cured.
If the cancer is very advanced, the tumor(s) can no longer be surgically removed. The only option left, in many cases, is to control the cancer, try to slow down its progress, and focus on making the patient as comfortable as possible.
It is vital that the medical team explains all the options to the patient - including their pros and cons - and if necessary, to his/her loved ones and/or caregivers. Fighting the cancer aggressively may mean enduring very unpleasant side effects, while just focusing on pain and quality of life for the remaining time, might be a better option. This is something the patient needs to discuss thoroughly with the medical team, and perhaps family members or close friends.
Surgery - this means removing tumors by surgery. Surgery is usually only an option during the early stages of the cancer. It may remove the whole cancer, or at least reduce some symptoms and slow it down.
If the cancer is very advanced, the tumor(s) can no longer be surgically removed. The only option left, in many cases, is to control the cancer, try to slow down its progress, and focus on making the patient as comfortable as possible.
It is vital that the medical team explains all the options to the patient - including their pros and cons - and if necessary, to his/her loved ones and/or caregivers. Fighting the cancer aggressively may mean enduring very unpleasant side effects, while just focusing on pain and quality of life for the remaining time, might be a better option. This is something the patient needs to discuss thoroughly with the medical team, and perhaps family members or close friends.
Surgery - this means removing tumors by surgery. Surgery is usually only an option during the early stages of the cancer. It may remove the whole cancer, or at least reduce some symptoms and slow it down.
- Fluid accumulation in the lung area -
surgery may be recommended if there is fluid accumulation in the chest,
resulting in breathing difficulties. The fluid is drained with a tube or
catheter. A drug may be injected into the chest to stop a recurrence of
fluid build-up. Drugs, such as tetracycline, talc powder, or bleomycin are
instilled inside the space between the two layers of tissue lining the
lungs (pleura); this causes inflammation, making the two
pleura tack together, leaving no space for fluid build-up. Treatment for
preventing this type of fluid build-up is called pleurodesis.
- Pleurectomy or peritonectomy - the lining
around the lungs or abdominal cavity may be surgically removed. The aim is
to relieve mesothelioma symptoms.
- Debulking - removing as much of the tumor as
possible, if it is not possible to remove all of it.
- Removing a lung - signs and symptoms may
be relieved if the surgeon removes the affected lung and its surrounding
tissue. This will be followed by radiotherapy.
Chemotherapy - if tumors cannot be surgically removed, chemotherapy may
help shrink them, as well as to slow down their progress. Neoadjuvant
chemotherapy may also be recommended - administering chemotherapy before
surgery which can make it easier to remove a tumor. Chemotherapy used after
surgery to try to prevent recurrence is called adjuvant chemotherapy.
Radiotherapy - also known as radiation therapy. For those with pleural mesothelioma, it may help relieve symptoms. Radiotherapy is sometimes administered to prevent metastasis after biopsy or surgery.
Radiotherapy - also known as radiation therapy. For those with pleural mesothelioma, it may help relieve symptoms. Radiotherapy is sometimes administered to prevent metastasis after biopsy or surgery.
Clinical trials - human studies using novel treatment methods. The patient
should discuss what the trial is about, as well as what to expect
realistically, thoroughly with the doctor.
What is the prognosis for mesothelioma?
Cancer is a very unpredictable
disease, and providing an accurate prognosis is not easy.
In general, prognoses for patients with mesothelioma are not encouraging. Malignant mesothelioma is a very aggressive type of cancer; it also has a long latency period. In the majority of cases, the disease is only detected when it is already in an advanced stage.
In most cases, survival for pleural malignant mesothelioma after diagnosis is no more than one or two years. The patient needs to bear in mind that there are exceptions, and new treatments are being researched and appear all the time.
Written by Christian Nordqvist
In general, prognoses for patients with mesothelioma are not encouraging. Malignant mesothelioma is a very aggressive type of cancer; it also has a long latency period. In the majority of cases, the disease is only detected when it is already in an advanced stage.
In most cases, survival for pleural malignant mesothelioma after diagnosis is no more than one or two years. The patient needs to bear in mind that there are exceptions, and new treatments are being researched and appear all the time.
Written by Christian Nordqvist
Source: http://www.medicalnewstoday.com/articles/140859.php
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